3BWI

Crystal structure of the catalytic domain of botulinum neurotoxin serotype A with an acetate ion bound at the active site

3BWI の概要

• エントリーDOI: 10.2210/pdb3bwi/pdb
• 分子名称: Botulinum neurotoxin A light chain, ZINC ION, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: botulinum neurotoxin type a, catalytic domain, endopeptidase, bio-warfare agent, hydrolase, metalloprotease, pharmaceutical, protease, secreted, zinc
• 由来する生物種: Clostridium botulinum
• 細胞内の位置: Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: A5HZZ9
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 49974.57

構造登録者

Kumaran, D.,Rawat, R.,Swaminathan, S. (登録日: 2008-01-09, 公開日: 2008-04-22, 最終更新日: 2023-08-30)

• 主引用文献: Kumaran, D.,Rawat, R.,Ludivico, M.L.,Ahmed, S.A.,Swaminathan, S.; Structure- and Substrate-based Inhibitor Design for Clostridium botulinum Neurotoxin Serotype A; J.Biol.Chem., 283:18883-18891, 2008; PubMed: 18434312; DOI: 10.1074/jbc.M801240200

実験手法

X-RAY DIFFRACTION (1.7 Å)