3BVB

Cystal structure of HIV-1 Active Site Mutant D25N and inhibitor Darunavir

3BVB の概要

• エントリーDOI: 10.2210/pdb3bvb/pdb
• 関連するPDBエントリー: 3BVA
• 分子名称: Protease (Retropepsin), SODIUM ION, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: drug resistance; hiv-1; d25n, mutant, aids, aspartyl protease, capsid maturation, core protein, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, hydrolase, lipoprotein, magnesium, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphoprotein, protease, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc-finger
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22177.58

構造登録者

Liu, F.,Weber, I.T. (登録日: 2008-01-05, 公開日: 2008-04-01, 最終更新日: 2023-08-30)

• 主引用文献: Sayer, J.M.,Liu, F.,Ishima, R.,Weber, I.T.,Louis, J.M.; Effect of the Active Site D25N Mutation on the Structure, Stability, and Ligand Binding of the Mature HIV-1 Protease.; J.Biol.Chem., 283:13459-13470, 2008; PubMed: 18281688; DOI: 10.1074/jbc.M708506200

実験手法

X-RAY DIFFRACTION (1.3 Å)