3BUW

Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Syk

3BUW の概要

• エントリーDOI: 10.2210/pdb3buw/pdb
• 関連するPDBエントリー: 3BUM 3BUN 3BUO 3BUX
• 分子名称: 13-meric peptide from Tyrosine-protein kinase SYK, E3 ubiquitin-protein ligase CBL (3 entities in total)
• 機能のキーワード: cbl, tkb, ligase, signal transduction, proto-oncogene, complex, alternative splicing, atp-binding, host-virus interaction, kinase, nucleotide-binding, phosphoprotein, polymorphism, sh2 domain, transferase, tyrosine-protein kinase, ubl conjugation, calcium, cytoplasm, metal-binding, ubl conjugation pathway, zinc, zinc-finger, ligase-signaling protein complex, ligase/signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane : P43405; Cytoplasm: P22681
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 79471.31

構造登録者

Ng, C.,Jackson, R.A.,Buschdorf, J.P.,Sun, Q.,Guy, G.R.,Sivaraman, J. (登録日: 2008-01-03, 公開日: 2008-02-26, 最終更新日: 2023-11-15)

• 主引用文献: Ng, C.,Jackson, R.A.,Buschdorf, J.P.,Sun, Q.,Guy, G.R.,Sivaraman, J.; Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates; Embo J., 27:804-816, 2008; PubMed: 18273061; DOI: 10.1038/emboj.2008.18

実験手法

X-RAY DIFFRACTION (1.45 Å)