3BUR

Crystal structure of Delta(4)-3-ketosteroid 5-beta-reductase in complex with NADP and TESTOSTERONE. RESOLUTION: 1.62 A.

Summary for 3BUR

Entry DOI	10.2210/pdb3bur/pdb
Related	3BUV 3BV7
Descriptor	3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TESTOSTERONE, ... (5 entities in total)
Functional Keywords	5beta-reductase; catalytic tetrad; testosterone; nadp, bile acid catabolism, disease mutation, lipid metabolism, oxidoreductase, steroid metabolism
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P51857
Total number of polymer chains	2
Total formula weight	77840.39
Authors	Di Costanzo, L.,Christianson, D.W. (deposition date: 2008-01-03, release date: 2008-04-01, Last modification date: 2023-08-30)
Primary citation	Di Costanzo, L.,Drury, J.E.,Penning, T.M.,Christianson, D.W. Crystal Structure of Human Liver {Delta}4-3-Ketosteroid 5{beta}-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis. J.Biol.Chem., 283:16830-16839, 2008 Cited by PubMed: 18407998 DOI: 10.1074/jbc.M801778200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.62 Å)

Structure validation