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3BUF

BACE-1 complexed with compound 2

Summary for 3BUF
Entry DOI10.2210/pdb3buf/pdb
Related3BRA 3BUG 3BUH
DescriptorBeta-secretase 1, 4-[(2R)-2-aminopropyl]phenol (3 entities in total)
Functional Keywordsalzheimer's disease, aspartic protease, beta-secretase, memapsin 2, fragment screen, alternative splicing, aspartyl protease, glycoprotein, hydrolase, membrane, transmembrane, zymogen
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: P56817
Total number of polymer chains1
Total formula weight45705.21
Authors
Kuglstatter, A.,Hennig, M. (deposition date: 2008-01-02, release date: 2008-03-11, Last modification date: 2021-11-10)
Primary citationKuglstatter, A.,Stahl, M.,Peters, J.U.,Huber, W.,Stihle, M.,Schlatter, D.,Benz, J.,Ruf, A.,Roth, D.,Enderle, T.,Hennig, M.
Tyramine fragment binding to BACE-1
Bioorg.Med.Chem.Lett., 18:1304-1307, 2008
Cited by
PubMed: 18226904
DOI: 10.1016/j.bmcl.2008.01.032
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

217705

数据于2024-03-27公开中

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