3BO8

The High Resolution Crystal Structure of HLA-A1 Complexed with the MAGE-A1 Peptide

3BO8 の概要

• エントリーDOI: 10.2210/pdb3bo8/pdb
• 関連するPDBエントリー: 1W72
• 分子名称: HLA class I histocompatibility antigen, A-1 alpha chain, Beta-2-microglobulin, nonameric peptide from Melanoma-associated antigen 1, ... (5 entities in total)
• 機能のキーワード: melanoma associated antigen, mage, mage-a1, major histocompatibility complex, mhc, human leukocyte antigen, hla, hla-a1, hla-a010101, tcr, t-cell receptor, antibody, fab-hyb3, hyb3, glycoprotein, host-virus interaction, immune response, immunoglobulin domain, membrane, mhc i, sulfation, transmembrane, disease mutation, glycation, pyrrolidone carboxylic acid, secreted, tumor antigen, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P30443; Secreted: P61769; Cytoplasm: P43355
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44769.56

構造登録者

Kumar, P.,Vahedi-Faridi, A.,Saenger, W.,Ziegler, A.,Uchanska-Ziegler, B. (登録日: 2007-12-17, 公開日: 2008-12-23, 最終更新日: 2023-11-01)

• 主引用文献: Kumar, P.,Vahedi-Faridi, A.,Saenger, W.,Ziegler, A.,Uchanska-Ziegler, B.; Conformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like specificity; Protein Sci., 18:37-49, 2009; PubMed: 19177349; DOI: 10.1002/pro.4

実験手法

X-RAY DIFFRACTION (1.8 Å)