Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol

Summary for 3BLR

Related3BLH 3BLQ
DescriptorCell division protein kinase 9, Cyclin-T1, PHOSPHATE ION, ... (5 entities in total)
Functional Keywordstranscriptional cdk-cyclin complex, phosphorylated, flavopiridol, alternative splicing, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transcription regulation, transferase, acetylation, cell cycle, cell division, coiled coil, host-virus interaction, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus P50750 O60563
Total number of polymer chains2
Total molecular weight68860.26
Baumli, S.,Lolli, G.,Lowe, E.D.,Johnson, L.N. (deposition date: 2007-12-11, release date: 2008-07-01, Last modification date: 2011-07-13)
Primary citation
Baumli, S.,Lolli, G.,Lowe, E.D.,Troiani, S.,Rusconi, L.,Bullock, A.N.,Debreczeni, J.E.,Knapp, S.,Johnson, L.N.
The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation
Embo J., 27:1907-1918, 2008
PubMed: 18566585 (PDB entries with the same primary citation)
DOI: 10.1038/emboj.2008.121
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22080.2%2.4%3.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report