3BKK

Tesis ACE co-crystal structure with ketone ACE inhibitor kAF

3BKK の概要

• エントリーDOI: 10.2210/pdb3bkk/pdb
• 関連するPDBエントリー: 1O86 1O8A 1UZE 1UZF 2IUL 2IUX 3BKL
• 分子名称: Angiotensin-converting enzyme, somatic isoform, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: enzyme-inhibitor complex, gem-diol, domain-selective, carboxypeptidase, glycoprotein, hydrolase, membrane, metal-binding, metalloprotease, phosphoprotein, protease, secreted, transmembrane
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 69921.05

構造登録者

Watermeyer, J.M.,Kroger, W.L.,O'Neill, H.G.,Sewell, B.T.,Sturrock, E.D. (登録日: 2007-12-07, 公開日: 2008-06-10, 最終更新日: 2023-08-30)

• 主引用文献: Watermeyer, J.M.,Kroger, W.L.,O'Neill, H.G.,Sewell, B.T.,Sturrock, E.D.; Probing the basis of domain-dependent inhibition using novel ketone inhibitors of Angiotensin-converting enzyme; Biochemistry, 47:5942-5950, 2008; PubMed: 18457420; DOI: 10.1021/bi8002605

実験手法

X-RAY DIFFRACTION (2.17 Å)