3BI6
Wee1 kinase complex with inhibitor PD352396
3BI6 の概要
エントリーDOI | 10.2210/pdb3bi6/pdb |
関連するPDBエントリー | 1x8b 2in6 2io6 2z2w |
分子名称 | Wee1-like protein kinase, CHLORIDE ION, 4-(2-chlorophenyl)-9-hydroxy-6-methyl-1,3-dioxo-N-(2-pyrrolidin-1-ylethyl)pyrrolo[3,4-g]carbazole-8-carboxamide, ... (4 entities in total) |
機能のキーワード | kinase domain, inhibitor complex, atp-binding, cell cycle, cell division, magnesium, metal-binding, mitosis, nucleotide-binding, nucleus, phosphoprotein, transferase, tyrosine-protein kinase, ubl conjugation |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Nucleus: P30291 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 32849.20 |
構造登録者 | Squire, C.J.,Dickson, J.M.,Ivanovic, I.,Baker, E.N. (登録日: 2007-11-29, 公開日: 2007-12-18, 最終更新日: 2023-11-01) |
主引用文献 | Smaill, J.B.,Lee, H.H.,Palmer, B.D.,Thompson, A.M.,Squire, C.J.,Baker, E.N.,Booth, R.J.,Kraker, A.,Hook, K.,Denny, W.A. Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases. Bioorg.Med.Chem.Lett., 18:929-933, 2008 Cited by PubMed: 18191399DOI: 10.1016/j.bmcl.2007.12.046 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.2 Å) |
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