3BI0

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a transition state analog of Glu-Glu

3BI0 の概要

• エントリーDOI: 10.2210/pdb3bi0/pdb
• 関連するPDBエントリー: 3BHX 3BI1
• 分子名称: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: prostate specific membrane antigen; metallopeptidase; folate hydrolase; glutamate carboxypeptidase ii; naaladase, dipeptidase, glycoprotein, metal-binding, metalloprotease, multifunctional enzyme, protease, signal-anchor, transmembrane, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 83062.11

構造登録者

Lubkowski, J.,Barinka, C. (登録日: 2007-11-29, 公開日: 2008-01-08, 最終更新日: 2023-08-30)

• 主引用文献: Barinka, C.,Hlouchova, K.,Rovenska, M.,Majer, P.,Dauter, M.,Hin, N.,Ko, Y.S.,Tsukamoto, T.,Slusher, B.S.,Konvalinka, J.,Lubkowski, J.; Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs; J.Mol.Biol., 376:1438-1450, 2008; PubMed: 18234225; DOI: 10.1016/j.jmb.2007.12.066

実験手法

X-RAY DIFFRACTION (1.67 Å)