3BGR

Crystal structure of K103N/Y181C mutant HIV-1 reverse transcriptase (RT) in complex with TMC278 (Rilpivirine), a non-nucleoside RT inhibitor

3BGR の概要

• エントリーDOI: 10.2210/pdb3bgr/pdb
• 関連するPDBエントリー: 1S6Q 1SV5 2IC3 2ZD1 2ZE2
• 分子名称: Reverse transcriptase/ribonuclease H, p51 RT, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... (5 entities in total)
• 機能のキーワード: p51/p66, hetero dimer, nnrti, nonnucleoside inhibitor, aids, hiv, r278474, rilpivirine, diarylpyrimidine, dapy, dna recombination, rna-directed dna polymerase, dna polymerase, endonuclease, hydrolase, multifunctional enzyme, transferase, k103n, y181c
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 114382.10

構造登録者

Das, K.,Bauman, J.D.,Clark Jr., A.D.,Shatkin, A.J.,Arnold, E. (登録日: 2007-11-27, 公開日: 2008-02-12, 最終更新日: 2023-11-01)

• 主引用文献: Das, K.,Bauman, J.D.,Clark Jr., A.D.,Frenkel, Y.V.,Lewi, P.J.,Shatkin, A.J.,Hughes, S.H.,Arnold, E.; High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations.; Proc.Natl.Acad.Sci.Usa, 105:1466-1471, 2008; PubMed: 18230722; DOI: 10.1073/pnas.0711209105

実験手法

X-RAY DIFFRACTION (2.1 Å)