3BG3

Crystal Structure of Human Pyruvate Carboxylase (missing the biotin carboxylase domain at the N-terminus)

Summary for 3BG3

Entry DOI	10.2210/pdb3bg3/pdb
Related	1rqh 3BG5 3BG9
Descriptor	Pyruvate carboxylase, mitochondrial, MANGANESE (II) ION, PYRUVIC ACID, ... (4 entities in total)
Functional Keywords	tim barrel, atp-binding, biotin, disease mutation, gluconeogenesis, ligase, lipid synthesis, manganese, mitochondrion, multifunctional enzyme, nucleotide-binding, phosphoprotein, transit peptide
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion matrix: P11498
Total number of polymer chains	4
Total formula weight	316157.56
Authors	Xiang, S.,Tong, L. (deposition date: 2007-11-26, release date: 2008-02-26, Last modification date: 2023-11-15)
Primary citation	Xiang, S.,Tong, L. Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction. Nat.Struct.Mol.Biol., 15:295-302, 2008 Cited by PubMed: 18297087 DOI: 10.1038/nsmb.1393 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation