3BEL

X-ray structure of EGFR in complex with oxime inhibitor

3BEL の概要

• エントリーDOI: 10.2210/pdb3bel/pdb
• 関連するPDBエントリー: 2RGP
• 分子名称: Epidermal growth factor receptor, PHOSPHATE ION, 4-amino-6-{[1-(3-fluorobenzyl)-1H-indazol-5-yl]amino}pyrimidine-5-carbaldehyde O-(2-methoxyethyl)oxime, ... (4 entities in total)
• 機能のキーワード: kinase domain, alternative splicing, anti-oncogene, atp-binding, cell cycle, disease mutation, glycoprotein, membrane, nucleotide-binding, phosphoprotein, polymorphism, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase, ubl conjugation
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36696.21

構造登録者

Abad, M.C.,Xu, G.,Neeper, M.P.,Struble, G.T.,Gaul, M.D.,Connolly, P.J. (登録日: 2007-11-19, 公開日: 2008-07-01, 最終更新日: 2023-08-30)

• 主引用文献: Xu, G.,Searle, L.L.,Hughes, T.V.,Beck, A.K.,Connolly, P.J.,Abad, M.C.,Neeper, M.P.,Struble, G.T.,Springer, B.A.,Emanuel, S.L.,Gruninger, R.H.,Pandey, N.,Adams, M.,Moreno-Mazza, S.,Fuentes-Pesquera, A.R.,Middleton, S.A.,Greenberger, L.M.; Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases.; Bioorg.Med.Chem.Lett., 18:3495-3499, 2008; PubMed: 18508264; DOI: 10.1016/j.bmcl.2008.05.024

実験手法

X-RAY DIFFRACTION (2.3 Å)