3BE9
Structure-based design and synthesis of novel macrocyclic pyrazolo[1,5-a] [1,3,5]triazine compounds as potent inhibitors of protein kinase CK2 and their anticancer activities
3BE9 の概要
エントリーDOI | 10.2210/pdb3be9/pdb |
関連するPDBエントリー | 2PVH 2PVJ 2PVK 2PVL 2PVM 2PVN |
分子名称 | Casein kinase II subunit alpha, 19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one (3 entities in total) |
機能のキーワード | structure-based drug design, enzyme-inhibitor complex, casein kinase ii, protein kinase ck2, atp-binding, nucleotide-binding, serine/threonine-protein kinase, transferase |
由来する生物種 | Zea mays (Maize) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 41813.88 |
構造登録者 | Nie, Z.,Perretta, C.,Erickson, P.,Margosiak, S.,Lu, J.,Averill, A.,Almassy, R.,Chu, S. (登録日: 2007-11-16, 公開日: 2008-11-18, 最終更新日: 2023-11-15) |
主引用文献 | Nie, Z.,Perretta, C.,Erickson, P.,Margosiak, S.,Lu, J.,Averill, A.,Almassy, R.,Chu, S. Structure-based design and synthesis of novel macrocyclic pyrazolo[1,5-a] [1,3,5]triazine compounds as potent inhibitors of protein kinase CK2 and their anticancer activities. Bioorg.Med.Chem.Lett., 18:619-623, 2008 Cited by PubMed: 18055206DOI: 10.1016/j.bmcl.2007.11.074 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
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