3BCG

Conformational changes of the AcrR regulator reveal a mechanism of induction

3BCG の概要

• エントリーDOI: 10.2210/pdb3bcg/pdb
• 分子名称: HTH-type transcriptional regulator acrR (2 entities in total)
• 機能のキーワード: acrb regulator, dna-binding, repressor, transcription, transcription regulation, dna binding protein, transcription regulator
• 由来する生物種: Escherichia coli K12
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49595.32

構造登録者

Gu, R.,Li, M.,Su, C.C.,Long, F.,Yang, F.,McDermott, G.,Yu, E.Y. (登録日: 2007-11-12, 公開日: 2008-02-26, 最終更新日: 2024-02-21)

主引用文献

Gu, R.,Li, M.,Su, C.C.,Long, F.,Routh, M.D.,Yang, F.,McDermott, G.,Yu, E.W.
Conformational change of the AcrR regulator reveals a possible mechanism of induction.
Acta Crystallogr.,Sect.F, 64:584-588, 2008

PubMed Abstract: The Escherichia coli AcrR multidrug-binding protein represses transcription of acrAB and is induced by many structurally unrelated cytotoxic compounds. The crystal structure of AcrR in space group P222(1) has been reported previously. This P222(1) structure has provided direct information about the multidrug-binding site and important residues for drug recognition. Here, a crystal structure of this regulator in space group P3(1) is presented. Comparison of the two AcrR structures reveals possible mechanisms of ligand binding and AcrR regulation.

PubMed: 18607081
DOI: 10.1107/S1744309108016035

実験手法

X-RAY DIFFRACTION (2.48 Å)