3BC5

X-ray crystal structure of human ppar gamma with 2-(5-(3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)-2-phenyl-2h-1,2,3-triazol-4-yl)acetic acid

3BC5 の概要

• エントリーDOI: 10.2210/pdb3bc5/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, (5-{3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]benzyl}-2-phenyl-2H-1,2,3-triazol-4-yl)acetic acid (3 entities in total)
• 機能のキーワード: ligand-binding domain, nuclear hormone receptor, transcription factor, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphorylation, polymorphism, transcription regulation, zinc, zinc-finger, transcription
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34246.61

構造登録者

Muckelbauer, J.K. (登録日: 2007-11-12, 公開日: 2008-11-18, 最終更新日: 2024-02-21)

• 主引用文献: Zhang, H.,Ryono, D.E.,Devasthale, P.,Wang, W.,O'Malley, K.,Farrelly, D.,Gu, L.,Harrity, T.,Cap, M.,Chu, C.,Locke, K.,Zhang, L.,Lippy, J.,Kunselman, L.,Morgan, N.,Flynn, N.,Moore, L.,Hosagrahara, V.,Zhang, L.,Kadiyala, P.,Xu, C.,Doweyko, A.M.,Bell, A.,Chang, C.,Muckelbauer, J.,Zahler, R.,Hariharan, N.,Cheng, P.T.; Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.; Bioorg.Med.Chem.Lett., 19:1451-1456, 2009; PubMed: 19201606; DOI: 10.1016/j.bmcl.2009.01.030

実験手法

X-RAY DIFFRACTION (2.27 Å)