3BC5

X-ray crystal structure of human ppar gamma with 2-(5-(3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)-2-phenyl-2h-1,2,3-triazol-4-yl)acetic acid

3BC5 の概要

• エントリーDOI: 10.2210/pdb3bc5/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, (5-{3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]benzyl}-2-phenyl-2H-1,2,3-triazol-4-yl)acetic acid (3 entities in total)
• 機能のキーワード: ligand-binding domain, nuclear hormone receptor, transcription factor, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphorylation, polymorphism, transcription regulation, zinc, zinc-finger, transcription
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34246.61

構造登録者

Muckelbauer, J.K. (登録日: 2007-11-12, 公開日: 2008-11-18, 最終更新日: 2024-02-21)

主引用文献

Zhang, H.,Ryono, D.E.,Devasthale, P.,Wang, W.,O'Malley, K.,Farrelly, D.,Gu, L.,Harrity, T.,Cap, M.,Chu, C.,Locke, K.,Zhang, L.,Lippy, J.,Kunselman, L.,Morgan, N.,Flynn, N.,Moore, L.,Hosagrahara, V.,Zhang, L.,Kadiyala, P.,Xu, C.,Doweyko, A.M.,Bell, A.,Chang, C.,Muckelbauer, J.,Zahler, R.,Hariharan, N.,Cheng, P.T.
Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.
Bioorg.Med.Chem.Lett., 19:1451-1456, 2009

PubMed Abstract: The design, synthesis and structure-activity relationships of a novel series of N-phenyl-substituted pyrrole, 1,2-pyrazole and 1,2,3-triazole acid analogs as PPAR ligands are outlined. The triazole acid analogs 3f and 4f were identified as potent dual PPARalpha/gamma agonists both in binding and functional assays in vitro. The 3-oxybenzyl triazole acetic acid analog 3f showed excellent glucose and triglyceride lowering in diabetic db/db mice.

PubMed: 19201606
DOI: 10.1016/j.bmcl.2009.01.030

実験手法

X-RAY DIFFRACTION (2.27 Å)