3BBB

Crystal structure of the NM23-H2 transcription factor complex with dinucleotide d(AG)

3BBB の概要

• エントリーDOI: 10.2210/pdb3bbb/pdb
• 関連するPDBエントリー: 1NUE 3BBC 3BBF
• 分子名称: Nucleoside diphosphate kinase B, DNA (5'-D(*AP*G)-3') (3 entities in total)
• 機能のキーワード: transcription factor, cancer, nm23 gen, hexamer, activator, anti-oncogene, atp-binding, cell cycle, dna-binding, kinase, magnesium, metal-binding, nucleotide metabolism, nucleotide-binding, nucleus, phosphorylation, transcription regulation, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm: P22392
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 105546.97

構造登録者

Weichsel, A.,Montfort, W.R. (登録日: 2007-11-09, 公開日: 2008-09-23, 最終更新日: 2024-05-29)

• 主引用文献: Dexheimer, T.S.,Carey, S.S.,Zuohe, S.,Gokhale, V.M.,Hu, X.,Murata, L.B.,Maes, E.M.,Weichsel, A.,Sun, D.,Meuillet, E.J.,Montfort, W.R.,Hurley, L.H.; NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1.; Mol.Cancer Ther., 8:1363-1377, 2009; PubMed: 19435876; DOI: 10.1158/1535-7163.MCT-08-1093

実験手法

X-RAY DIFFRACTION (1.3 Å)