3B7V

HIV-1 protease complexed with gem-diol-amine tetrahedral intermediate NLLTQI

Summary for 3B7V

Related3B80
Related PRD IDPRD_000321
DescriptorProtease, peptide, SODIUM ION, ... (6 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus type 1 BH10
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion  P04587
Total number of polymer chains3
Total molecular weight22421.64
Authors
Kovalevsky, A.Y.,Chumanevich, A.A.,Weber, I.T. (deposition date: 2007-10-31, release date: 2007-12-18, Last modification date: 2017-10-25)
Primary citation
Kovalevsky, A.Y.,Chumanevich, A.A.,Liu, F.,Louis, J.M.,Weber, I.T.
Caught in the Act: The 1.5 A Resolution Crystal Structures of the HIV-1 Protease and the I54V Mutant Reveal a Tetrahedral Reaction Intermediate.
Biochemistry, 46:14854-14864, 2007
PubMed: 18052235 (PDB entries with the same primary citation)
DOI: 10.1021/bi700822g
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.46 Å)
NMR Information
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2021101.8%3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3b7v
no rotation
Molmil generated image of 3b7v
rotated about x axis by 90°
Molmil generated image of 3b7v
rotated about y axis by 90°