3B4F

Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies

3B4F の概要

• エントリーDOI: 10.2210/pdb3b4f/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, MERCURY (II) ION, ... (5 entities in total)
• 機能のキーワード: carbonic anhydrase, inhibitors, sulfonamide, acetylation, cytoplasm, disease mutation, lyase, metal-binding, polymorphism, zinc, lyase(oxo-acid)
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29885.42

構造登録者

Guzel, o.,Temperini, c.,Innocenti, a.,Scozzafava, A.,Salman, a.,Supuran, c.t. (登録日: 2007-10-24, 公開日: 2008-01-22, 最終更新日: 2023-08-30)

• 主引用文献: Guzel, O.,Temperini, C.,Innocenti, A.,Scozzafava, A.,Salman, A.,Supuran, C.T.; Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.; Bioorg.Med.Chem.Lett., 18:152-158, 2008; PubMed: 18024029; DOI: 10.1016/j.bmcl.2007.10.110

実験手法

X-RAY DIFFRACTION (1.89 Å)