3B23

Crystal structure of thrombin-variegin complex: Insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors

Summary for 3B23

Entry DOI	10.2210/pdb3b23/pdb
Descriptor	Thrombin light chain, Thrombin heavy chain, Variegin, ... (4 entities in total)
Functional Keywords	hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space: P00734 P00734 Secreted: P85800
Total number of polymer chains	3
Total formula weight	37488.58
Authors	Koh, C.Y.,Kumar, S.,Swaminathan, K.,Kini, R.M. (deposition date: 2011-07-20, release date: 2011-11-23, Last modification date: 2023-11-01)
Primary citation	Koh, C.Y.,Kumar, S.,Kazimirova, M.,Nuttall, P.A.,Radhakrishnan, U.P.,Kim, S.,Jagadeeswaran, P.,Imamura, T.,Mizuguchi, J.,Iwanaga, S.,Swaminathan, K.,Kini, R.M. Crystal structure of thrombin in complex with s-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors Plos One, 6:e26367-e26367, 2011 Cited by PubMed: 22053189 DOI: 10.1371/journal.pone.0026367 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation