3B23
Crystal structure of thrombin-variegin complex: Insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors
Summary for 3B23
Entry DOI | 10.2210/pdb3b23/pdb |
Descriptor | Thrombin light chain, Thrombin heavy chain, Variegin, ... (4 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P85800 |
Total number of polymer chains | 3 |
Total formula weight | 37488.58 |
Authors | Koh, C.Y.,Kumar, S.,Swaminathan, K.,Kini, R.M. (deposition date: 2011-07-20, release date: 2011-11-23, Last modification date: 2023-11-01) |
Primary citation | Koh, C.Y.,Kumar, S.,Kazimirova, M.,Nuttall, P.A.,Radhakrishnan, U.P.,Kim, S.,Jagadeeswaran, P.,Imamura, T.,Mizuguchi, J.,Iwanaga, S.,Swaminathan, K.,Kini, R.M. Crystal structure of thrombin in complex with s-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors Plos One, 6:e26367-e26367, 2011 Cited by PubMed: 22053189DOI: 10.1371/journal.pone.0026367 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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