3B23

Crystal structure of thrombin-variegin complex: Insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors

3B23 の概要

• エントリーDOI: 10.2210/pdb3b23/pdb
• 分子名称: Thrombin light chain, Thrombin heavy chain, Variegin, ... (4 entities in total)
• 機能のキーワード: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734; Secreted: P85800
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 37488.58

構造登録者

Koh, C.Y.,Kumar, S.,Swaminathan, K.,Kini, R.M. (登録日: 2011-07-20, 公開日: 2011-11-23, 最終更新日: 2023-11-01)

• 主引用文献: Koh, C.Y.,Kumar, S.,Kazimirova, M.,Nuttall, P.A.,Radhakrishnan, U.P.,Kim, S.,Jagadeeswaran, P.,Imamura, T.,Mizuguchi, J.,Iwanaga, S.,Swaminathan, K.,Kini, R.M.; Crystal structure of thrombin in complex with s-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors; Plos One, 6:e26367-e26367, 2011; PubMed: 22053189; DOI: 10.1371/journal.pone.0026367

実験手法

X-RAY DIFFRACTION (2.4 Å)