3AXW

Crystal structure of human CK2alpha complexed with a potent inhibitor

3AXW の概要

• エントリーDOI: 10.2210/pdb3axw/pdb
• 分子名称: Casein kinase II subunit alpha, 4-(5-amino-1,3,4-thiadiazol-2-yl)benzoic acid (3 entities in total)
• 機能のキーワード: kinase domain, serine/threonine kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40699.43

構造登録者

Kinoshita, T.,Nakanishi, I. (登録日: 2011-04-18, 公開日: 2012-04-04, 最終更新日: 2024-03-13)

• 主引用文献: Hou, Z.,Nakanishi, I.,Kinoshita, T.,Takei, Y.,Yasue, M.,Misu, R.,Suzuki, Y.,Nakamura, S.,Kure, T.,Ohno, H.,Murata, K.,Kitaura, K.,Hirasawa, A.,Tsujimoto, G.,Oishi, S.,Fujii, N.; Structure-Based Design of Novel Potent Protein Kinase CK2 (CK2) Inhibitors with Phenyl-azole Scaffolds; J.Med.Chem., 55:2899-2903, 2012; PubMed: 22339433; DOI: 10.1021/jm2015167

実験手法

X-RAY DIFFRACTION (2.5 Å)