3AUQ

Crystal structure of the human vitamin D receptor ligand binding domain complexed with Yne-diene type analog of active 14-epi-2alpha-methyl-19-norvitamin D3

3AUQ の概要

• エントリーDOI: 10.2210/pdb3auq/pdb
• 分子名称: Vitamin D3 receptor, (1R,2S,3R)-5-[2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-1,2,3,3a,6,7-hexahydroinden-4-yl]ethynyl]-2-methyl-cyclohex-4-ene-1,3-diol (3 entities in total)
• 機能のキーワード: hormone receptor, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P11473
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30219.96

構造登録者

Kakuda, S.,Takimoto-Kamimura, M. (登録日: 2011-02-15, 公開日: 2011-09-14, 最終更新日: 2023-11-01)

• 主引用文献: Sawada, D.,Tsukuda, Y.,Saito, H.,Kakuda, S.,Takimoto-Kamimura, M.,Ochiai, E.,Takenouchi, K.,Kittaka, A.; Development of 14-epi-19-nortachysterol and its unprecedented binding configuration for the human vitamin D receptor; J.Am.Chem.Soc., 133:7215-7221, 2011; PubMed: 21500802; DOI: 10.1021/ja201481j

実験手法

X-RAY DIFFRACTION (2.64 Å)