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3ATW

Structure-Based Design, Synthesis, Evaluation of Peptide-mimetic SARS 3CL Protease Inhibitors

Summary for 3ATW
Entry DOI10.2210/pdb3atw/pdb
Related PRD IDPRD_000815
Descriptor3C-Like Proteinase, peptide ACE-THR-VAL-ALC-HIS-H (3 entities in total)
Functional Keywordshydrase proteinase converting, designed inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceSARS coronavirus (SARS-CoV)
More
Cellular locationNon-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region : P0C6U8
Total number of polymer chains4
Total formula weight68704.52
Authors
Akaji, K.,Konno, H.,Mitsui, H.,Teruya, K.,Hattori, Y.,Ozaki, T.,Kusunoki, M.,Sanjho, A. (deposition date: 2011-01-20, release date: 2011-12-14, Last modification date: 2023-11-15)
Primary citationAkaji, K.,Konno, H.,Mitsui, H.,Teruya, K.,Shimamoto, Y.,Hattori, Y.,Ozaki, T.,Kusunoki, M.,Sanjoh, A.
Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors.
J.Med.Chem., 54:7962-7973, 2011
Cited by
PubMed: 22014094
DOI: 10.1021/jm200870n
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.36 Å)
Structure validation

217705

数据于2024-03-27公开中

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