3ATW

Structure-Based Design, Synthesis, Evaluation of Peptide-mimetic SARS 3CL Protease Inhibitors

3ATW の概要

• エントリーDOI: 10.2210/pdb3atw/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000815
• 分子名称: 3C-Like Proteinase, peptide ACE-THR-VAL-ALC-HIS-H (3 entities in total)
• 機能のキーワード: hydrase proteinase converting, designed inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: SARS coronavirus (SARS-CoV); 詳細
• 細胞内の位置: Non-structural protein 3: Host membrane ; Multi-pass membrane protein . Non-structural protein 4: Host membrane ; Multi-pass membrane protein . Non-structural protein 6: Host membrane ; Multi-pass membrane protein . Non-structural protein 7: Host cytoplasm, host perinuclear region . Non-structural protein 8: Host cytoplasm, host perinuclear region . Non-structural protein 9: Host cytoplasm, host perinuclear region . Non-structural protein 10: Host cytoplasm, host perinuclear region : P0C6U8
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 68704.52

構造登録者

Akaji, K.,Konno, H.,Mitsui, H.,Teruya, K.,Hattori, Y.,Ozaki, T.,Kusunoki, M.,Sanjho, A. (登録日: 2011-01-20, 公開日: 2011-12-14, 最終更新日: 2023-11-15)

• 主引用文献: Akaji, K.,Konno, H.,Mitsui, H.,Teruya, K.,Shimamoto, Y.,Hattori, Y.,Ozaki, T.,Kusunoki, M.,Sanjoh, A.; Structure-Based Design, Synthesis, and Evaluation of Peptide-Mimetic SARS 3CL Protease Inhibitors.; J.Med.Chem., 54:7962-7973, 2011; PubMed: 22014094; DOI: 10.1021/jm200870n

実験手法

X-RAY DIFFRACTION (2.36 Å)