3ATH

Crystal structure of Pyrococcus horikoshii kynurenine aminotransferase in complex with four AKGs as substrates and allosteric effectors

Summary for 3ATH

• Entry DOI: 10.2210/pdb3ath/pdb
• Related: 3AOV 3AOW
• Descriptor: Putative uncharacterized protein PH0207, PYRIDOXAL-5'-PHOSPHATE, 2-OXOGLUTARIC ACID, ... (4 entities in total)
• Functional Keywords: cofactor-substrate-allosteric effector complex, aminotransferase, plp binding, 2og binding, transamination, cytosol, transferase
• Biological source: Pyrococcus horikoshii
• Total number of polymer chains: 2
• Total formula weight: 103404.47

Authors

Okada, K.,Angkawidjaja, C.,Koga, Y.,Takano, K.,Kanaya, S. (deposition date: 2011-01-05, release date: 2012-01-18, Last modification date: 2023-11-01)

• Primary citation: Okada, K.,Angkawidjaja, C.,Koga, Y.,Takano, K.,Kanaya, Y.; Characterization of kynurenine aminotransferase from hyperthermophilic archaeon: enzymatic activity for conversion to kynurenic acid is allosterically regulated by alpha-ketoglutaric acid cooperatively with kynurenine; To be Published,

Experimental method

X-RAY DIFFRACTION (1.69 Å)