3ATH

Crystal structure of Pyrococcus horikoshii kynurenine aminotransferase in complex with four AKGs as substrates and allosteric effectors

3ATH の概要

• エントリーDOI: 10.2210/pdb3ath/pdb
• 関連するPDBエントリー: 3AOV 3AOW
• 分子名称: Putative uncharacterized protein PH0207, PYRIDOXAL-5'-PHOSPHATE, 2-OXOGLUTARIC ACID, ... (4 entities in total)
• 機能のキーワード: cofactor-substrate-allosteric effector complex, aminotransferase, plp binding, 2og binding, transamination, cytosol, transferase
• 由来する生物種: Pyrococcus horikoshii
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 103404.47

構造登録者

Okada, K.,Angkawidjaja, C.,Koga, Y.,Takano, K.,Kanaya, S. (登録日: 2011-01-05, 公開日: 2012-01-18, 最終更新日: 2023-11-01)

• 主引用文献: Okada, K.,Angkawidjaja, C.,Koga, Y.,Takano, K.,Kanaya, Y.; Characterization of kynurenine aminotransferase from hyperthermophilic archaeon: enzymatic activity for conversion to kynurenic acid is allosterically regulated by alpha-ketoglutaric acid cooperatively with kynurenine; To be Published,

実験手法

X-RAY DIFFRACTION (1.69 Å)