3ARN
Human dUTPase in complex with novel uracil derivative
Summary for 3ARN
Entry DOI | 10.2210/pdb3arn/pdb |
Related | 2HQU 3ARA |
Descriptor | Deoxyuridine 5'-triphosphate nucleotidohydrolase, N-{5-[(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy]-2-methylpentan-2-yl}benzenesulfonamide, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 2: Nucleus . Isoform 3: Mitochondrion : P33316 |
Total number of polymer chains | 3 |
Total formula weight | 54603.38 |
Authors | Chong, K.T.,Miyahara, S.,Miyakoshi, H.,Fukuoka, M. (deposition date: 2010-12-03, release date: 2010-12-15, Last modification date: 2024-03-13) |
Primary citation | Miyahara, S.,Miyakoshi, H.,Yokogawa, T.,Chong, K.T.,Taguchi, J.,Muto, T.,Endoh, K.,Yano, W.,Wakasa, T.,Ueno, H.,Takao, Y.,Fujioka, A.,Hashimoto, A.,Itou, K.,Yamamura, K.,Nomura, M.,Nagasawa, H.,Shuto, S.,Fukuoka, M. Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors J.Med.Chem., 55:2970-2980, 2012 Cited by PubMed: 22339362DOI: 10.1021/jm201628y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report