3AQE

Crystal structure of the extracellular domain of human RAMP2

3AQE の概要

• エントリーDOI: 10.2210/pdb3aqe/pdb
• 関連するPDBエントリー: 3AQF
• 分子名称: Receptor activity-modifying protein 2 (2 entities in total)
• 機能のキーワード: transmembrane, gpcr, adrenomedullin, trafficking, clr, cgrp, endoplasmic reticulum, disease, neovascularization, helix bundle, calcitonin receptor-like receptor (crlr), endoplasmic reticulum (er), cell membrane, transport protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: O60895
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 63488.83

構造登録者

Kusano, S.,Kukimoto-Niino, M.,Shirouzu, M.,Shindo, T.,Yokoyama, S. (登録日: 2010-10-29, 公開日: 2011-11-09, 最終更新日: 2012-07-25)

• 主引用文献: Kusano, S.,Kukimoto-Niino, M.,Hino, N.,Ohsawa, N.,Okuda, K.,Sakamoto, K.,Shirouzu, M.,Shindo, T.,Yokoyama, S.; Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding; Protein Sci., 21:199-210, 2012; PubMed: 22102369; DOI: 10.1002/pro.2003

実験手法

X-RAY DIFFRACTION (2 Å)