3AQA

Crystal structure of the human BRD2 BD1 bromodomain in complex with a BRD2-interactive compound, BIC1

3AQA の概要

• エントリーDOI: 10.2210/pdb3aqa/pdb
• 分子名称: Bromodomain-containing protein 2, 1-[2-(1H-benzimidazol-2-ylsulfanyl)ethyl]-3-methyl-1,3-dihydro-2H-benzimidazole-2-thione, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
• 機能のキーワード: structural genomics, riken structural genomics/proteomics initiative, rsgi, helical bundle, acetyl-lysine recognition, acetylated histone h4, nucleus, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus (By similarity): P25440
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 46323.36

構造登録者

Umehara, T.,Nakamura, Y.,Terada, T.,Shirouzu, M.,Padmanabhan, B.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2010-10-27, 公開日: 2011-05-18, 最終更新日: 2024-10-16)

• 主引用文献: Ito, T.,Umehara, T.,Sasaki, K.,Nakamura, Y.,Nishino, N.,Terada, T.,Shirouzu, M.,Padmanabhan, B.,Yokoyama, S.,Ito, A.,Yoshida, M.; Real-Time Imaging of Histone H4K12-Specific Acetylation Determines the Modes of Action of Histone Deacetylase and Bromodomain Inhibitors; Chem.Biol., 18:495-507, 2011; PubMed: 21513886; DOI: 10.1016/j.chembiol.2011.02.009

実験手法

X-RAY DIFFRACTION (2.3 Å)