3APC

Crystal structure of human PI3K-gamma in complex with CH5132799

3APC の概要

• エントリーDOI: 10.2210/pdb3apc/pdb
• 関連するPDBエントリー: 3APD 3APF
• 分子名称: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 5-(7-Methanesulfonyl-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-ylamine, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: phosphoinositide 3-kinase gamma, kinase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 111017.35

構造登録者

Nakamura, M.,Fukami, T.A.,Miyazaki, T.,Yoshida, M. (登録日: 2010-10-14, 公開日: 2011-04-13, 最終更新日: 2023-11-01)

• 主引用文献: Ohwada, J.,Ebiike, H.,Kawada, H.,Tsukazaki, M.,Nakamura, M.,Miyazaki, T.,Morikami, K.,Yoshinari, K.,Yoshida, M.,Kondoh, O.,Kuramoto, S.,Ogawa, K.,Aoki, Y.,Shimma, N.; Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799; Bioorg.Med.Chem.Lett., 21:1767-1772, 2011; PubMed: 21316229; DOI: 10.1016/j.bmcl.2011.01.065

実験手法

X-RAY DIFFRACTION (2.544 Å)