3AOD

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

Summary for 3AOD

• Entry DOI: 10.2210/pdb3aod/pdb
• Related: 3AOA 3AOB 3AOC
• Descriptor: Acriflavine resistance protein B, (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, RIFAMPICIN, ... (4 entities in total)
• Functional Keywords: membrane protein, inner membrane, membrane protein-antibiotic complex, membrane protein/antibiotic
• Biological source: Escherichia coli
• Cellular location: Cell inner membrane ; Multi- pass membrane protein : P31224
• Total number of polymer chains: 3
• Total formula weight: 343933.64

Authors

Nakashima, R.,Sakurai, K.,Yamaguchi, A. (deposition date: 2010-09-23, release date: 2011-11-30, Last modification date: 2023-11-01)

• Primary citation: Nakashima, R.,Sakurai, K.,Yamasaki, S.,Nishino, K.,Yamaguchi, A.; Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket; Nature, 480:565-569, 2011; PubMed: 22121023; DOI: 10.1038/nature10641

Experimental method

X-RAY DIFFRACTION (3.3 Å)