3AOD
Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket
Summary for 3AOD
Entry DOI | 10.2210/pdb3aod/pdb |
Related | 3AOA 3AOB 3AOC |
Descriptor | Acriflavine resistance protein B, (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, RIFAMPICIN, ... (4 entities in total) |
Functional Keywords | membrane protein, inner membrane, membrane protein-antibiotic complex, membrane protein/antibiotic |
Biological source | Escherichia coli |
Cellular location | Cell inner membrane ; Multi- pass membrane protein : P31224 |
Total number of polymer chains | 3 |
Total formula weight | 343933.64 |
Authors | Nakashima, R.,Sakurai, K.,Yamaguchi, A. (deposition date: 2010-09-23, release date: 2011-11-30, Last modification date: 2023-11-01) |
Primary citation | Nakashima, R.,Sakurai, K.,Yamasaki, S.,Nishino, K.,Yamaguchi, A. Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket Nature, 480:565-569, 2011 Cited by PubMed: 22121023DOI: 10.1038/nature10641 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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