3AO1
Fragment-based approach to the design of ligands targeting a novel site in HIV-1 integrase
Summary for 3AO1
Entry DOI | 10.2210/pdb3ao1/pdb |
Related | 3AO2 3AO3 3AO4 3AO5 3l3u 3OVN |
Descriptor | POL polyprotein, CADMIUM ION, SULFATE ION, ... (5 entities in total) |
Functional Keywords | dna integration, aids, integrase, endonuclease, polynucleotidyl transferase, dna binding, viral protein, rnaseh, fragment binding, viral protein-transferase inhibitor complex, viral protein/transferase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 36564.42 |
Authors | Wielens, J.,Parker, M.W.,Chalmers, D.K.,Scanlon, M.J. (deposition date: 2010-09-17, release date: 2011-03-09, Last modification date: 2023-11-01) |
Primary citation | Wielens, J.,Headey, S.J.,Deadman, J.J.,Rhodes, D.I.,Parker, M.W.,Chalmers, D.K.,Scanlon, M.J. Fragment-based design of ligands targeting a novel site on the integrase enzyme of human immunodeficiency virus 1 Chemmedchem, 6:258-261, 2011 Cited by PubMed: 21275048DOI: 10.1002/cmdc.201000483 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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