3AMB

Protein kinase A sixfold mutant model of Aurora B with inhibitor VX-680

3AMB の概要

• エントリーDOI: 10.2210/pdb3amb/pdb
• 関連するPDBエントリー: 3AMA
• 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, ... (4 entities in total)
• 機能のキーワード: pka, protein kinase a, surrogate, vx-680, mk-0457, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm: P17612
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43547.47

構造登録者

Pflug, A.,de Oliveira, T.M.,Bossemeyer, D.,Engh, R.A. (登録日: 2010-08-18, 公開日: 2011-08-03, 最終更新日: 2023-11-01)

• 主引用文献: Pflug, A.,de Oliveira, T.M.,Bossemeyer, D.,Engh, R.A.; Mutants of protein kinase A that mimic the ATP-binding site of Aurora kinase; Biochem.J., 440:85-93, 2011; PubMed: 21774789; DOI: 10.1042/BJ20110592

実験手法

X-RAY DIFFRACTION (2.25 Å)