3AE9

Crystal structure of porcine heart mitochondrial complex II bound with N-(3-Pentafluorophenyloxy-phenyl)-2-trifluoromethyl-benzamide

3AE9 の概要

• エントリーDOI: 10.2210/pdb3ae9/pdb
• 関連するPDBエントリー: 3ABV 3AE1 3AE2 3AE3 3AE4 3AE5 3AE6 3AE7 3AE8 3AEA 3AEB 3AEC 3AED 3AEE 3AEF 3AEG
• 分子名称: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE, N-[3-(pentafluorophenoxy)phenyl]-2-(trifluoromethyl)benzamide, ... (12 entities in total)
• 機能のキーワード: respiratory complex ii, inhibitors, electron transport, iron, iron-sulfur, metal-binding, mitochondrion, mitochondrion inner membrane, oxidoreductase, transit peptide, transport, tricarboxylic acid cycle, heme, transmembrane, fad-binding protein, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Sus scrofa (Pig); 詳細
• 細胞内の位置: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side : Q0QF01 Q007T0; Mitochondrion inner membrane ; Multi-pass membrane protein : D0VWV4 A5GZW8
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 126802.78

構造登録者

Harada, S.,Sasaki, T.,Shindo, M.,Kido, Y.,Inaoka, D.K.,Omori, J.,Osanai, A.,Sakamoto, K.,Mao, J.,Matsuoka, S.,Inoue, M.,Honma, T.,Tanaka, A.,Kita, K. (登録日: 2010-02-04, 公開日: 2011-02-09, 最終更新日: 2023-11-01)

• 主引用文献: Inaoka, D.K.,Shiba, T.,Sato, D.,Balogun, E.O.,Sasaki, T.,Nagahama, M.,Oda, M.,Matsuoka, S.,Ohmori, J.,Honma, T.,Inoue, M.,Kita, K.,Harada, S.; Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria; Int J Mol Sci, 16:15287-15308, 2015; PubMed: 26198225; DOI: 10.3390/ijms160715287

実験手法

X-RAY DIFFRACTION (3.31 Å)