3ADE
Crystal Structure of Keap1 in Complex with Sequestosome-1/p62
Summary for 3ADE
Entry DOI | 10.2210/pdb3ade/pdb |
Descriptor | Kelch-like ECH-associated protein 1, Sequestosome-1, SULFATE ION, ... (4 entities in total) |
Functional Keywords | beta-propeller, kelch motif, transcription |
Biological source | Mus musculus (mouse) More |
Cellular location | Cytoplasm: Q9Z2X8 Q64337 |
Total number of polymer chains | 2 |
Total formula weight | 37402.49 |
Authors | Kurokawa, H.,Yamamoto, M. (deposition date: 2010-01-19, release date: 2010-03-16, Last modification date: 2023-11-01) |
Primary citation | Komatsu, M.,Kurokawa, H.,Waguri, S.,Taguchi, K.,Kobayashi, A.,Ichimura, Y.,Sou, Y.S.,Ueno, I.,Sakamoto, A.,Tong, K.I.,Kim, M.,Nishito, Y.,Iemura, S.,Natsume, T.,Ueno, T.,Kominami, E.,Motohashi, H.,Tanaka, K.,Yamamoto, M. The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 Nat.Cell Biol., 12:213-223, 2010 Cited by PubMed: 20173742DOI: 10.1038/ncb2021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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