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3AC8

Crystal structure of pyrazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)

Summary for 3AC8
Entry DOI10.2210/pdb3ac8/pdb
Related3AC1 3AC2 3AC3 3AC4 3AC5 3ACJ 3ACK 3LCK
DescriptorProto-oncogene tyrosine-protein kinase LCK, SULFATE ION, 7-[(2-amino-2-methylpropyl)amino]-5-cyclopropyl-2-[(3,5-dimethoxyphenyl)amino]pyrazolo[1,5-a]pyrimidine-3-carboxamide, ... (4 entities in total)
Functional Keywordstyrosine-protein kinase, atp-binding, phosphorylation, signal transduction, alternative splicing, kinase, sh2 domain, sh3 domain, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm : P06239
Total number of polymer chains1
Total formula weight33697.24
Authors
Tsuji, E. (deposition date: 2009-12-29, release date: 2010-06-30, Last modification date: 2023-11-15)
Primary citationOzawa, M.,Ozawa, T.,Tsuji, E.,Okazaki, K.,Takeda, K.
Ab initio fragment molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase
To be Published,
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

217705

數據於2024-03-27公開中

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