3AC4

Crystal structure of triazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)

Summary for 3AC4

• Entry DOI: 10.2210/pdb3ac4/pdb
• Related: 3AC1 3AC2 3AC3 3AC5 3AC8 3ACJ 3ACK 3LCK
• Descriptor: Proto-oncogene tyrosine-protein kinase LCK, SULFATE ION, DIMETHYL SULFOXIDE, ... (5 entities in total)
• Functional Keywords: tyrosine-protein kinase, atp-binding, phosphorylation, signal transduction, alternative splicing, kinase, sh2 domain, sh3 domain, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P06239
• Total number of polymer chains: 1
• Total formula weight: 33736.30

Authors

Tsuji, E. (deposition date: 2009-12-28, release date: 2010-06-30, Last modification date: 2024-10-30)

• Primary citation: Ozawa, M.,Ozawa, T.,Tsuji, E.,Okazaki, K.,Takeda, K.; Ab initio fragment molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase; To be Published,

Experimental method

X-RAY DIFFRACTION (2.7 Å)