3AC3
Crystal structure of pyrazolo pyrimidine derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)
Summary for 3AC3
Entry DOI | 10.2210/pdb3ac3/pdb |
Related | 3AC1 3AC2 3AC4 3AC5 3AC8 3ACJ 3ACK 3LCK |
Descriptor | Proto-oncogene tyrosine-protein kinase LCK, SULFATE ION, 2-[(3,5-dimethoxyphenyl)amino]-5-ethyl-7-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, ... (4 entities in total) |
Functional Keywords | tyrosine-protein kinase, atp-binding, phosphorylation, signal transduction, alternative splicing, kinase, sh2 domain, sh3 domain, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P06239 |
Total number of polymer chains | 1 |
Total formula weight | 33698.22 |
Authors | Tsuji, E. (deposition date: 2009-12-28, release date: 2010-06-30, Last modification date: 2023-11-15) |
Primary citation | Ozawa, M.,Ozawa, T.,Tsuji, E.,Okazaki, K.,Takeda, K. Ab initio fragment molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase To be Published, |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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