3ABT
Crystal Structure of LSD1 in complex with trans-2-pentafluorophenylcyclopropylamine
3ABT の概要
エントリーDOI | 10.2210/pdb3abt/pdb |
関連するPDBエントリー | 2dw4 2uxx 2z5u 3abu |
分子名称 | Lysine-specific histone demethylase 1, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl (2R,3S,4S)-2,3,4-trihydroxy-5-[(1R,3R,3aS)-1-hydroxy-10,11-dimethyl-4,6-dioxo-3-(pentafluorophenyl)-2,3,5,6-tetrahydro-1H-benzo[g]pyrrolo[2,1-e]pteridin-8(4H)-yl]pentyl dihydrogen diphosphate (2 entities in total) |
機能のキーワード | amine oxidase, histone demethylase, tower domain, h3k4, structural genomics, riken structural genomics/proteomics initiative, rsgi, chromatin regulator, developmental protein, fad, nucleus, oxidoreductase, phosphoprotein, repressor, transcription, transcription regulation, nppsfa, national project on protein structural and functional analyses |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Nucleus : O60341 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 74661.92 |
構造登録者 | Mimasu, S.,Umezawa, N.,Sato, S.,Higuchi, T.,Umehara, T.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2009-12-21, 公開日: 2010-07-07, 最終更新日: 2023-11-01) |
主引用文献 | Mimasu, S.,Umezawa, N.,Sato, S.,Higuchi, T.,Umehara, T.,Yokoyama, S. Structurally Designed trans-2-Phenylcyclopropylamine Derivatives Potently Inhibit Histone Demethylase LSD1/KDM1 Biochemistry, 49:6494-6503, 2010 Cited by PubMed: 20568732DOI: 10.1021/bi100299r 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.2 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード