3ABA

Crystal structure of CYP105P1 in complex with filipin I

3ABA の概要

• エントリーDOI: 10.2210/pdb3aba/pdb
• 関連するPDBエントリー: 3ABB 3E5J 3E5K 3E5L
• 分子名称: Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE, (3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25E,28R)-3-hexyl-4,6,8,10,12,14,16-heptahydroxy-17,28-dimethyloxacyclooctacosa-17,19,21,23,25-pentaen-2-one, ... (5 entities in total)
• 機能のキーワード: p450, oxidoreductase, heme, monooxygenase, macrolide, filipin, iron, metal-binding, oxidoreductase-antibiotic complex, oxidoreductase/antibiotic
• 由来する生物種: Streptomyces avermitilis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45957.00

構造登録者

Xu, L.H.,Fushinobu, S.,Takamatsu, S.,Wakagi, T.,Ikeda, H.,Shoun, H. (登録日: 2009-12-04, 公開日: 2010-04-07, 最終更新日: 2023-11-01)

• 主引用文献: Xu, L.H.,Fushinobu, S.,Takamatsu, S.,Wakagi, T.,Ikeda, H.,Shoun, H.; Regio- and stereospecificity of filipin hydroxylation sites revealed by crystal structures of cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis; J.Biol.Chem., 285:16844-16853, 2010; PubMed: 20375018; DOI: 10.1074/jbc.M109.092460

実験手法

X-RAY DIFFRACTION (1.8 Å)