3A99

Structure of PIM-1 kinase crystallized in the presence of P27KIP1 Carboxy-terminal peptide

3A99 の概要

• エントリーDOI: 10.2210/pdb3a99/pdb
• 分子名称: Proto-oncogene serine/threonine-protein kinase pim-1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
• 機能のキーワード: pim-1, p27kip1, peptide drug, prostate cancer, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37013.89

構造登録者

Morishita, D.,Takami, M.,Yoshikawa, S.,Katayama, R.,Sato, S.,Kukimoto-Niino, M.,Umehara, T.,Shirouzu, M.,Sekimizu, K.,Yokoyama, S.,Fujita, N. (登録日: 2009-10-22, 公開日: 2010-11-03, 最終更新日: 2023-11-01)

• 主引用文献: Morishita, D.,Takami, M.,Yoshikawa, S.,Katayama, R.,Sato, S.,Kukimoto-Niino, M.,Umehara, T.,Shirouzu, M.,Sekimizu, K.,Yokoyama, S.,Fujita, N.; Cell-permeable carboxyl-terminal p27(Kip1) peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase; J.Biol.Chem., 286:2681-2688, 2011; PubMed: 21062737; DOI: 10.1074/jbc.M109.092452

実験手法

X-RAY DIFFRACTION (1.6 Å)