3A7D
Crystal Structures of rat Catechol-O-Methyltransferase complexed with new bi-substrate type inhibitor
3A7D の概要
エントリーDOI | 10.2210/pdb3a7d/pdb |
関連するPDBエントリー | 1JR4 1VID 3A7E |
分子名称 | Catechol O-methyltransferase, MAGNESIUM ION, SULFATE ION, ... (5 entities in total) |
機能のキーワード | methyltransferase, neurotransmitter degradation, alternative initiation, catecholamine metabolism, s-adenosyl-l-methionine, cell membrane, magnesium, membrane, metal-binding, phosphoprotein, signal-anchor, transferase, transmembrane |
由来する生物種 | Rattus norvegicus (Rat) |
細胞内の位置 | Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 25661.40 |
構造登録者 | |
主引用文献 | Muranaka, H.,Nakatsu, M.,Tsuji, E.,Okazaki, K. Hit to Lead: Comprehensive Strategy of de novo Scaffold Generation by FBDD. Part 2: Ligand Fishing using Mass Spectrometry by Detection of Ligand-Protein Non-Covalent Complex after Matrix Click Chemistry To be Published, |
実験手法 |
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