3A7D

Crystal Structures of rat Catechol-O-Methyltransferase complexed with new bi-substrate type inhibitor

3A7D の概要

• エントリーDOI: 10.2210/pdb3a7d/pdb
• 関連するPDBエントリー: 1JR4 1VID 3A7E
• 分子名称: Catechol O-methyltransferase, MAGNESIUM ION, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: methyltransferase, neurotransmitter degradation, alternative initiation, catecholamine metabolism, s-adenosyl-l-methionine, cell membrane, magnesium, membrane, metal-binding, phosphoprotein, signal-anchor, transferase, transmembrane
• 由来する生物種: Rattus norvegicus (Rat)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25661.40

構造登録者

Tsuji, E. (登録日: 2009-09-26, 公開日: 2010-09-15, 最終更新日: 2023-11-01)

• 主引用文献: Muranaka, H.,Nakatsu, M.,Tsuji, E.,Okazaki, K.; Hit to Lead: Comprehensive Strategy of de novo Scaffold Generation by FBDD. Part 2: Ligand Fishing using Mass Spectrometry by Detection of Ligand-Protein Non-Covalent Complex after Matrix Click Chemistry; To be Published,

実験手法

X-RAY DIFFRACTION (2.4 Å)