3ZME
Structure of the p53 core domain mutant Y220C bound to the small molecule PhiKan7242
Summary for 3ZME
Entry DOI | 10.2210/pdb3zme/pdb |
Descriptor | Cellular tumor antigen p53, ZINC ION, 2-(4-(4-fluorophenyl)-5-(1H-pyrrol-1-yl)-1H-pyrazol-1-yl)-N,N-dimethylethanamine, ... (4 entities in total) |
Functional Keywords | transcription, cell cycle, apoptosis, cancer mutation, protein stabilization |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 49789.16 |
Authors | Joerger, A.C.,Wilcken, R. (deposition date: 2013-02-07, release date: 2013-05-08, Last modification date: 2024-05-08) |
Primary citation | Liu, X.,Wilcken, R.,Joerger, A.C.,Chuckowree, I.S.,Amin, J.,Spencer, J.,Fersht, A.R. Small molecule induced reactivation of mutant p53 in cancer cells. Nucleic Acids Res., 41:6034-6044, 2013 Cited by PubMed: 23630318DOI: 10.1093/nar/gkt305 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.35 Å) |
Structure validation
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