3ZFZ
Crystal structure of ceftaroline acyl-PBP2a from MRSA with non- covalently bound ceftaroline and muramic acid at allosteric site obtained by soaking
Summary for 3ZFZ
Entry DOI | 10.2210/pdb3zfz/pdb |
Related | 3ZG0 3ZG5 |
Descriptor | PENICILLIN BINDING PROTEIN 2 PRIME, CADMIUM ION, CHLORIDE ION, ... (7 entities in total) |
Functional Keywords | hydrolase, penicillin binding proteins, mrsa, allosteric site, b-lactam antibiotics |
Biological source | STAPHYLOCOCCUS AUREUS SUBSP. AUREUS MU50 |
Total number of polymer chains | 2 |
Total formula weight | 149330.32 |
Authors | Otero, L.H.,Rojas-Altuve, A.,Hermoso, J.A. (deposition date: 2012-12-13, release date: 2013-10-09, Last modification date: 2023-12-20) |
Primary citation | Otero, L.H.,Rojas-Altuve, A.,Llarrull, L.I.,Carrasco-Lopez, C.,Kumarasiri, M.,Lastochkin, E.,Fishovitz, J.,Dawley, M.,Hesek, D.,Lee, M.,Johnson, J.W.,Fisher, J.F.,Chang, M.,Mobashery, S.,Hermoso, J.A. How Allosteric Control of Staphylococcus Aureus Penicillin Binding Protein 2A Enables Methicillin Resistance and Physiological Function Proc.Natl.Acad.Sci.USA, 110:16808-16813, 2013 Cited by PubMed: 24085846DOI: 10.1073/PNAS.1300118110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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