3WN4
Crystal structure of human TLR8 in complex with DS-877
Summary for 3WN4
Entry DOI | 10.2210/pdb3wn4/pdb |
Descriptor | Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(2-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | leucine rich repeat, rna, glycosylation, innate immunity, rna recognition, ssrnar, structure-based ligand design, tlr8-specific agonist, vaccine adjuvants, antiviral-antitumor drug binding, immune system |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 97150.45 |
Authors | Tanji, H.,Ohto, U.,Shimizu, T. (deposition date: 2013-12-02, release date: 2014-02-19, Last modification date: 2022-08-24) |
Primary citation | Kokatla, H.P.,Sil, D.,Tanji, H.,Ohto, U.,Malladi, S.S.,Fox, L.M.,Shimizu, T.,David, S.A. Structure-based design of novel human Toll-like receptor 8 agonists. Chemmedchem, 9:719-723, 2014 Cited by PubMed: 24474703DOI: 10.1002/cmdc.201300573 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.81 Å) |
Structure validation
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