3WL9

HLA-A24 in complex with HIV-1 Nef126-10(8I10F)

Summary for 3WL9

• Entry DOI: 10.2210/pdb3wl9/pdb
• Related: 3WLB
• Descriptor: HLA class I histocompatibility antigen, A-24 alpha chain, Beta-2-microglobulin, Protein Nef, ... (4 entities in total)
• Functional Keywords: hiv-1, nef, hla-a24, mhc class i, immunogloburin domain, immune response, immune system, tcr, t cell receptor
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P05534; Secreted . Note=(Microbial infection) In the presence of M: P61769; Host cell membrane ; Lipid-anchor ; Cytoplasmic side : Q9Q5D4
• Total number of polymer chains: 3
• Total formula weight: 44684.70

Authors

Shimizu, A.,Fukai, S.,Yamagata, A.,Iwamoto, A.,Han, C. (deposition date: 2013-11-08, release date: 2014-06-11, Last modification date: 2024-10-16)

Primary citation

Han, C.,Kawana-tachikawa, A.,Shimizu, A.,Zhu, D.,Nakamura, H.,Adachi, E.,Kikuchi, T.,Koga, M.,Koibuchi, T.,Gao, G.F.,Sato, Y.,Yamagata, A.,Martin, E.,Fukai, S.,Brumme, Z.L.,Iwamoto, A.
Switching and emergence of CTL epitopes in HIV-1 infection
Retrovirology, 11:38-38, 2014

PubMed Abstract: Human Leukocyte Antigen (HLA) class I restricted Cytotoxic T Lymphocytes (CTLs) exert substantial evolutionary pressure on HIV-1, as evidenced by the reproducible selection of HLA-restricted immune escape mutations in the viral genome. An escape mutation from tyrosine to phenylalanine at the 135th amino acid (Y135F) of the HIV-1 nef gene is frequently observed in patients with HLA-A*24:02, an HLA Class I allele expressed in ~70% of Japanese persons. The selection of CTL escape mutations could theoretically result in the de novo creation of novel epitopes, however, the extent to which such dynamic "CTL epitope switching" occurs in HIV-1 remains incompletely known.

PubMed: 24886641
DOI: 10.1186/1742-4690-11-38

Experimental method

X-RAY DIFFRACTION (1.66 Å)