3WF5

Crystal structure of S6K1 kinase domain in complex with a pyrazolopyrimidine derivative 4-[4-(1H-benzimidazol-2-yl)piperidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine

Summary for 3WF5

Entry DOI	10.2210/pdb3wf5/pdb
Related	3WE4 3WF6 3WF7 3WF8 3WF9
Descriptor	Ribosomal protein S6 kinase beta-1, ZINC ION, 4-[4-(1H-benzimidazol-2-yl)piperidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine, ... (4 entities in total)
Functional Keywords	serine/threonine protein kinase domain, transferase, phosphorylation, atp-binding, zinc-binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell junction, synapse, synaptosome . Isoform Alpha I: Nucleus. Isoform Alpha II: Cytoplasm: P23443
Total number of polymer chains	1
Total formula weight	37563.59
Authors	Niwa, H.,Shirouzu, M.,Yokoyama, S. (deposition date: 2013-07-17, release date: 2014-08-06, Last modification date: 2014-10-29)
Primary citation	Niwa, H.,Mikuni, J.,Sasaki, S.,Tomabechi, Y.,Honda, K.,Ikeda, M.,Ohsawa, N.,Wakiyama, M.,Handa, N.,Shirouzu, M.,Honma, T.,Tanaka, A.,Yokoyama, S. Crystal structures of the S6K1 kinase domain in complexes with inhibitors J.Struct.Funct.Genom., 15:153-164, 2014 Cited by PubMed: 25078151 DOI: 10.1007/s10969-014-9188-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.099 Å)

Structure validation